(Note: This is the first draft protocol released
to local health departments on October 12, 2001. This protocol should be
followed until a final version can be released.)
Initial Assessment
by Local Public Health Agencies with Help from Infection Control Nurse
- Rapidly triage reports of respiratory disease by
gathering the following information:
- Number of ill persons
- Setting (school, nursing home, community, etc)
- Age distribution of ill persons
- Do ill individuals have underlying disease or
are they previously healthy?
- Symptoms
- Date(s) of onset of illness
- Duration of illness – time to full recovery
- Does anyone have pneumonia? How many?
- Results of sputum gram stain and blood
cultures, and other studies.
- Are any patients sick enough to be in the
hospital? How many?
- Are any patients moribund? How many?
- Has anyone died? How many?
- Name and phone number of person reporting
illness.
- If clusters of pneumonia resulting in critical
illness or deaths among previously healthy persons are identified
through initial triage, contact the Infectious Disease Epidemiology
Program (IDEP) immediately, day or night (at 304-558-5358 or
1-800-423-1271 from 8:30 AM to 5:00 PM or 304-558-4117 weekends and
after hours). Review the situation with IDEP. Anticipate that you will
be asked to:
- Immediately begin active surveillance with
other health care providers in the county.
- Alert your regional epidemiologist to expand
active surveillance throughout the region.
- Identify staffing for rapid response team(s) in
your county.
- If the pattern of illness suggests influenza A or
B or other seasonal respiratory illness, a rapid and efficient
outbreak investigation is helpful to document that illness is present
in the community and alert providers to take precautions with their
high risk patients. Consult IDEP ASAP.
- Pneumonia clusters may also be due to multiple
other diseases of public health significance: pneumococcus, Legionella,
leptospirosis, psittacosis, hantavirus, etc. Consult IDEP as soon
as possible.
- Pneumonia clusters and outbreaks may also be due
to mycoplasma, adenovirus, parainfluenza, RSV, etc. While state and
local health departments are often not as familiar with these
diseases, having a specific etiologic agent for an outbreak of
respiratory disease is very useful for educating and reassuring the
public and providers about what is going on in the community. Notify
IDEP.
Triage is the responsibility of medical
epidemiologist(s) within the Division of Surveillance and Disease Control.
- If medical epidemiologist(s) believe that the
possibility of a serious outbreak exists likely due to unintentional
causes, e.g., Legionellosis, invasive pneumococcal disease, then a
rapid response team should be formed with representation from the
state, regional epidemiologist and local health departments. That team
will go on-site to lead and complete the investigation.
- If medical epidemiologist(s) believe that there
is a possibility of a serious outbreak due to intentional causes,
then:
- Notification should proceed directly from
medical epidemiologist to the State Epidemiologist, and then to DHHR
Disaster Coordinator.
- The BT Coordinator (or alternate lead person
from DSDC) should then proceed to form Rapid Epi Response Teams,
usually one team per health care facility or closely located group
of health care facilities. Staffing on each team should generally
consist of a state and a regional or local person. Staffing must
remain flexible depending on need and case load. Any significant
back-log of case investigations must be addressed by swinging in
additional staff in a timely fashion. In the event that a disease
outbreak appears to be community-based, a street-based rapid epi
response team must also be formed.
- If there is a high probability of an
intentional incident, CDC should be consulted immediately at
770-488-7100.
Objectives/Purpose
of the Epidemiological Investigation and Response
- Establish the existence of an outbreak.
- Organize the information.
- Establish the most likely agent(s) responsible
for the outbreak through documentation of clinical signs and symptoms,
and person, place and time data, and assuring that adequate laboratory
testing is performed.
- Rapidly differentiate outbreak likely due to
unintentional causes versus intentional causes.
- For intentional outbreaks, determine the most
likely source of exposure through interviews of patients and family
members to identify common exposures during the incubation period of
the suspected agent.
- Based on the early information regarding
exposures, formulate recommendations for prophylaxis, if indicated.
For anthrax and plague, it may be necessary to make preliminary
recommendations for prophylaxis based on open-ended interview
information without performing a more rigorous case-control study.
- Conduct epidemiological investigations testing
hypotheses, as necessary.
- Identify / enumerate the population at risk so
that exposed / not yet symptomatic individuals can be prophylaxed and
emergency responders can anticipate supply, equipment and manpower
needs.
- Quantify and document ongoing human health
consequences to fully inform policymakers in real time.
- Evaluate (in real time) control strategies,
allowing readjustment as needed.
- Develop background information to inform public
and providers.
- Supply information for informed policy
development.
- Composition and duties
- State Epidemiologist - as always, primary
advocate for her staff. Identifies staffing, clears out barriers,
etc.
- Bioterrorism Coordinator - lead investigator /
lead communicator with teams in field, lead communicator on epi
issues with Public Health Command and Control. Link to CDC. Link to
USAMRIID. Link to weather info, if needed (prevailing wind
direction, etc. on day of event).
- Medical Epidemiologist(s) - clinical input into
study design and forms, draft recommendations for prophylaxis,
development of information for providers and the public on disease
manifestations, outcome, treatment, prophylaxis, etc. Divide time
between Rapid Epi Response Teams and the Central office.
- Data entry clerk - entry of study data.
- Epidemiologist(s) / analyst(s) - QA of data and
analysis, development of graphics, tables in real time to report
results, access census data to estimate population at risk in event
of community-based outbreak, GIS mapping.
- Functions
- Study design and oversight of data collection
and data management.
- Oversight of Rapid Epi Response Teams.
- Regular summarization of results to forward to
Public Health Command and Control:
- Enumeration of human health consequences
- Conclusions about etiology
- Information about the population thought to
be exposed and how and where they were exposed
- Estimates of size of population thought to be
at risk
- GIS maps showing location of cases in the
event of a community-based outbreak
- Real-time feedback of information on human
health consequences
- Development of recommendations for prophylaxis.
- Development of background information for
providers and public.
- Timely identification of staffing problems (too
many, too few, fatigue, stress, etc.) and timely referral to Public
Health Command and Control for resolution if the problems cannot be
resolved within DSDC.
- Communication and consultation with local
health departments and health care providers on medical and epi
issues.
- Communication with and consultation with CDC
and Ft Dietrich, as needed.
- Health care facility - based teams
- Functions
- Case finding
- Case ascertainment
- Data collection
- Assurance that clinical specimens are
obtained appropriately for diagnostic purposes
- Data transmittal to Central Epi Team
- Two way communication with Central Epi Team
- Two way communication with Infection Control
Practitioner or other hospital personnel
- Composition
- State employee with a clinical background
- Local health department employee with a
clinical background
- Infection control practitioner as liaison to
hospital / facility
- Medical Epidemiologist - on the first team
out, until the situation stabilizes, and as needed
- Street - based teams
- Functions
- Case finding
- Case ascertainment
- Outreach to exposed individuals who have not
sought medical care or other individuals who do not have access
for whatever reason
- Data collection, to include GIS data on cases
if needed to determine the extent of the exposure
- Direct one-on-one education of the public
- May be paired with medical outreach / home
health services
- Contact tracing
- Composition
- State employee(s) with clinical or
environmental background
- Health educator
- Local employee(s) with clinical or
environmental background
- Local law enforcement official, if judged
necessary for protection
DHHR Disaster Coordinator has the responsibility to
activate Public Health Command and Control.
- Functions
- Review and clearance of policy recommendations
from the Central Epi unit.
- Allocation and reallocation of staffing, as
needed.
- Organizing and oversight of implementation of
employee health functions, including provision of vaccine or
prophylactic antibiotics to employees, if needed
- Organizing and implementing employee advocacy,
to include counseling or other services to prevent post-traumatic
stress disorder in employees.
- Communications.
- Communication and coordination with EOC.
- Oversight of the logistics of medication and
vaccine distribution and delivery and organization of mass
prophylaxis clinics, if indicated.
- Host staff meeting at least daily for the
duration of the emergency.
- Monitoring stress / psychological response
among DHHR employees and proactively initiating counseling /
debriefing for employees
- Implementing employee health recommendations
appropriate for agent (may include provision of personal protective
equipment or prophylactic immunizations for employees in the field).
- Implementing employee health recommendations in
the event that HHR employees are exposed (if even by virtue of place
of residence) so that critical staffing can be maintained.
- Suggested composition
- State Health Commissioner
- State Epidemiologist
- BT Coordinator
- Emergency Medical Services
- Public Health Nursing and Administration
- HAN
- Office of Laboratory Services
- Office of Environmental Health
- DHHR Management Information Systems (MIS)
- West Virginia Department of Environmental
Protection (DEP)
- Bureau for Behavioral Health Services
There are five major BT agents that may present as
respiratory illness. Rapidly distinguishing between these agents is
critical because prophylactic antibiotics are effective against anthrax,
Q-Fever, Plague, and Tularemia; and suspicion of pneumonic plague
necessitates immediate isolation (droplet precautions) for all suspect
cases. Here is a quick rundown of key clinical and epidemiological signs
and symptoms that might be expected if patients present with respiratory
illness after covert release of an aerosolized biological agent:
Agent
|
Clinical Clues
|
Epidemiological Clues
|
Anthrax |
- Influenza-like prodrome with rapid
progression to death within 1-3 days
- Wide mediastinum and absence of
infiltrate on chest X-ray
|
- Cluster of respiratory disease in
previously healthy individuals with rapid progression to death
- Incubation 2-60 days
|
Pneumonic
Plague |
- Fever, cough, shortness of breath,
chest pain
- Hemoptysis is highly
characteristic
- GI symptoms common: nausea,
abdomenal pain, diarrhea
- Rapidly progressive pneumonia with
death in 2-6 days
|
- Cluster of pneumonia in previously
healthy individuals with rapid progression to death.
- Incubation 1-6 days, usually 2-4
days
|
Tularemia |
- Abrupt onset of fever, headache,
chills, rigors
- Progression to atypical pneumonia,
pleuritis, hilar adenopathy in some patients
- Mortality 35%
|
- Cluster of respiratory illness
with progression to pneumonia in previously healthy individuals,
especially off-season
- Incubation 1-14 days, usually 3-5
days.
|
Q-Fever |
- Non-differentiated febrile illness
lasting 2 days to 2 weeks
- Fever, headache, fatigue and
myalgia
- Abnormal Chest X-Ray in 50% and
cough in 25%
- Resolution without specific
therapy
|
- Cluster of respiratory illness,
especially in previously healthy persons, culture negative for
influenza and/or off-season.
- Incubation 2-14 days, average 7
days
|
Staphylococcal
enterotoxin B |
- Sudden onset of fever, chills,
headache, myalgia, and nonproductive cough
- Some patients may develop
shortness of breath and retrosternal chest pain
- Unremarkable physical exam and
usually normal CXR
- Fever lasts 2-5 days
- Cough lasts up to 4 weeks
- Higher exposures thought to result
in septic shock/death
|
- Cluster of patients with
influenza-like-illness presenting all on the same day
- Incubation 3-12 hours
|
Ricin |
- Exposure to sublethal doses
results in fever, chest tightness, cough, dyspnea, nausea, and
arthralgias. Onset of profuse sweating a few hours later heralds
recovery
- Exposure to larger doses may
result in progressive cough, dyspnea, cyanosis, pulmonary edema
and death within 36-72 hours after exposure.
|
- Cluster of patients with
influenza-like illness all presenting on the same day
- Incubation period 18-24 hours
|
Agent
|
Rapid Diagnosis
|
Confirmation
|
Anthrax |
-
Wide mediastinum
- Gram stain of peripheral blood to
look for gram (+) bacilli
|
|
Plague |
|
|
Tularemia |
|
|
Q Fever |
|
|
Staphylococcal enterotoxin B |
|
|
Ricin |
|
|
NOTE: In most situations, it is also important to
rule out other common infectious agents including influenza, respiratory
viruses, and legionella, pneumococcus, hantavirus, psittacosis, chlamydia
pneumoniae, etc.
Prophylaxis and Treatment - Major Concepts
See specifc recommendations from JAMA / USAMRIID.
Specific treatment and chemoprophylaxis is available
for anthrax, plague, tularemia, Q Fever. Treatment of respiratory ricin /
Staph enterotoxin B is supportive.
Isolation - Major Concepts
Standard precautions are sufficient for anthrax, Q
fever, tularemia, Staph enterotoxin B, and Ricin.
Droplet precautions must be used for pneumonic
plague.
Decontamination - Major Concept
Soap and water, if needed at all. Risk of secondary
aerosolization is negligible for all agents. (Not a good place to use
staff time)
Contact Tracing and Contact Assessment
Becomes critical for pneumonic plague. Should be
combined into the functions of the Street-based epi team(s). This would
necessitate expansion of the size and number of street epi team(s).
Exposed persons should be tracked and followed through the incubation
period and evaluated / isolated at first sign of illness. |